@article{nee-wun-70-bioseq,
  author = {Saul B. Needleman and Christian D. Wunsch},
  title = {A General Method Applicable to the Seacrh for Similarities in the Amino Acid sequence of two Proteins},
  journal = {Journal of Molecular Biology},
  volume = {48},
  pages = {443--453},
  year = 1970,
  comment = {First use of dynamic programming for biosequence comparison. Uses $\Theta(N^2)$ and space and at least that much time.}
}