@techreport{TR-IC-08-05,
  number = {IC-08-05},
  author = {P. P. Côgo and J. Meidanis},
  title = {A Rearrangement-Based Approach to Compare
           Whole Genomes of {V}ibrionaceae Strains},
  month = {February},
  year = {2008}, 
  institution = {Institute of Computing, University of Campinas},
  note = {In English, 13 pages.
    \par\selectlanguage{english}\textbf{Abstract}
       The Vibrionaceae family comprises a wide variety of organisms,
       including some severe human pathogens. Currently, 8 completely
       sequenced genomes are public available, and a natural challenge
       that arises from this scenario is to employ this information to
       establish a modern phylogeny.
       \par
       Toward this goal, we propose an approach based on genomic
       rearrangements to compare complete genomes of Vibrionaceae
       strains, which can in principle be applied, with adaptations,
       to other species. In our approach, we employ a profile-based
       methodology to identify homologous genes and model evolutionary
       events such as gene losses, lateral gene transfers, and
       chromosomal rearrangements to estimate evolutive distance,
       which we believe can substantially complement analyzes based on
       gene markers or phenotypic characteristics.
  }
}